England make three changes from their defeat in Dublin.
Fin Smith makes a first start at fly-half with Marcus Smith moving to full-back in place of Freddie Steward, who is dropped from the 23-man squad.
Tom Willis also makes his first Test start at number eight after coming off the bench in Dublin, with Ben Earl moving to openside flanker and Ben Curry dropping to the bench.
Ollie Sleightholme replaces Cadan Murley, who has been ruled out with a foot injury.
Fit-again Jamie George and Saracens team-mate Elliot Daly are brought into the replacements.
England: 15-M Smith; 14-Freeman, 13-Lawrence, 12-Slade, 11-Sleightholme; 10-F Smith, 9-Mitchell; 1-Genge, 2-Cowan-Dickie, 3-Stuart, 4-Itoje (capt), 5-Martin, 6-T Curry, 7-Earl, 8-Willis
Replacements: 16-George, 17-Baxter, 18-Heyes, 19-Chessum, 20-Cunningham-South, 21-B Curry, 22-Randall, 23-Daly
